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Cell culture studies have shown that NNMT inhibition increases intracellular NAD+ levels, enhances sirtuin activity, and shifts adipocyte metabolism toward greater fatty acid oxidation

However, when kidney function becomes compromised, this safety profile changes dramatically, making it worth having a deeper conversation with your healthcare provider

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Alcohol can increase the risk of hypoglycemia, particularly in patients with diabetes who are also taking insulin or sulfonylureas in combination with semaglutide